How Does Genetic Variation Affect Acetaldehyde Dehydrogenase Activity?
Genetic polymorphisms in the ALDH gene can significantly alter the enzyme's activity. For instance, individuals with the ALDH2*2 allele have a reduced ability to metabolize acetaldehyde, leading to its accumulation. This condition is more prevalent in East Asian populations and is associated with an increased risk of alcohol-related disorders and cancer. Understanding these genetic variations is important for assessing individual susceptibility to alcohol toxicity.
