What Role Does Acetaldehyde Dehydrogenase Play in Alcohol Use Disorders?
ALDH is central to understanding the development of alcohol use disorders (AUDs). Individuals with genetically reduced ALDH activity often experience unpleasant reactions to alcohol, which can act as a deterrent to excessive drinking. However, for those who continue to consume alcohol despite these reactions, the risk of developing AUDs and related health complications is significantly increased. In toxicology, assessing ALDH activity can help identify individuals at higher risk and inform prevention and treatment strategies for AUDs.
