How Does Monoamine Oxidase Inhibition Affect Toxicology?
Inhibitors of MAO, known as MAOIs, are used in the treatment of depression and anxiety disorders. However, they pose significant toxicological concerns due to their potential to interact with certain foods and drugs. MAOIs can lead to a dangerous condition called the "tyramine-induced hypertensive crisis," which occurs when tyramine-rich foods are consumed, causing a sudden and severe increase in blood pressure. Additionally, MAOIs can interact with serotonergic drugs, leading to serotonin syndrome, a potentially life-threatening condition characterized by increased serotonin levels.
