MAO inhibitors can interact with a wide range of medications, leading to severe toxicological outcomes. Drugs that increase serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) or certain opioids, can cause serotonin syndrome when taken with MAOIs. Additionally, sympathomimetic drugs, including over-the-counter decongestants, can lead to hypertensive crises when combined with MAOIs. It is crucial for healthcare providers to carefully manage and monitor these interactions to prevent adverse effects.
