Bioavailability refers to the extent and rate at which a substance enters systemic circulation, reaching its site of action. pH can significantly influence the bioavailability of toxins. In acidic conditions, weak acids remain non-ionized and can easily cross cell membranes, increasing their absorption. On the other hand, weak bases are more likely to cross membranes in alkaline conditions. Understanding these dynamics is essential for predicting the distribution and potential impact of toxic substances within an organism.
