Can RAD51 be a target for therapeutic interventions?
Given RAD51's role in DNA repair, it is a potential target for therapeutic interventions, particularly in cancer treatment. Some cancer cells exhibit overexpression of RAD51, which can contribute to resistance against chemotherapy and radiation therapy. Inhibiting RAD51 function in these cells can sensitize them to treatment, enhancing therapeutic efficacy. Conversely, enhancing RAD51 activity could be beneficial in conditions where increased DNA repair capacity is desired, such as in certain genetic disorders characterized by DNA repair deficiencies.
