How does TGF-beta relate to toxicological responses?
In toxicology, TGF-beta is often studied for its dual role in cell protection and promotion of pathological states. Following exposure to certain toxins, TGF-beta may be upregulated as a defensive mechanism to control inflammation and promote tissue repair. However, chronic activation of TGF-beta pathways can lead to fibrosis, a condition characterized by excessive deposition of extracellular matrix components, contributing to organ dysfunction.
