What are the challenges in targeting TGF-beta for therapeutic purposes?
Targeting TGF-beta for therapeutic purposes presents several challenges. Its ubiquitous presence and involvement in numerous physiological processes mean that systemic inhibition could lead to unintended side effects, such as impaired wound healing and immune suppression. Therefore, strategies that allow for localized modulation or selective targeting of specific TGF-beta isoforms are being explored to minimize adverse effects while maximizing therapeutic benefits.
