What are the implications of TGF-beta in drug toxicity?
TGF-beta is implicated in the toxicity profile of several drugs. Drugs that cause liver, kidney, or lung toxicity often do so by upregulating TGF-beta signaling pathways, leading to fibrotic changes in these organs. This makes TGF-beta a target for mitigating drug-induced toxicity. Pharmacological inhibition of TGF-beta signaling is being explored to prevent or reduce toxicity, especially in cases where fibrosis is a significant risk.
