How Does the Canonical Wnt Pathway Relate to Toxicology?
The canonical Wnt pathway is crucial in maintaining cellular homeostasis, and its dysregulation can lead to pathological conditions, including cancer. Toxicants can disrupt this pathway by either enhancing or inhibiting its components. For instance, certain environmental toxins can mimic Wnt ligands, leading to uncontrolled activation of the pathway, while others can inhibit the pathway, affecting normal cellular functions.
