The canonical Wnt pathway, also known as the Wnt/β-catenin pathway, involves the stabilization and translocation of β-catenin to the nucleus, where it regulates the expression of target genes. In the absence of Wnt signals, β-catenin is phosphorylated by a destruction complex, leading to its degradation. However, upon Wnt ligand binding to its receptor complexes, this destruction complex is inhibited, allowing β-catenin to accumulate and enter the nucleus.
