How Does the Non-Canonical Wnt Pathway Interact with Toxicants?
The non-canonical Wnt pathway can be affected by various environmental and chemical toxicants. Exposure to certain heavy metals, like cadmium and mercury, and organic compounds, such as dioxins, can disrupt Wnt signaling. These disruptions can lead to altered cell migration, increased oxidative stress, and changes in cell polarity, potentially leading to developmental abnormalities and diseases.
