tumor microenvironment

How does the tumor microenvironment influence toxicological responses?


The TME can alter the pharmacokinetics and pharmacodynamics of administered substances. For instance, the altered vasculature within tumors can affect drug delivery and distribution, often leading to hypoxic regions that influence drug efficacy. Furthermore, stromal cells and immune components can secrete factors that modulate the metabolism of toxicants, potentially leading to resistance or enhanced sensitivity to certain chemicals.

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