What role does the TME play in tumor progression and metastasis?
The TME supports tumor progression by facilitating processes such as angiogenesis, the formation of new blood vessels, which supply the growing tumor with nutrients and oxygen. Additionally, the TME provides a conducive environment for metastasis, where cancer cells detach and migrate to distant sites. Factors secreted by stromal and immune cells can promote epithelial-to-mesenchymal transition, a key step in metastasis, and support the survival of circulating tumor cells.
