What are the challenges in studying the tumor microenvironment in toxicological research?
Studying the TME in toxicological research presents several challenges, such as the complexity and heterogeneity of the TME across different cancer types and individual patients. Additionally, in vitro models often fail to fully replicate the intricate interactions present in vivo. Advanced techniques such as 3D culture systems and organ-on-a-chip technologies are being developed to better mimic the TME and improve the predictive accuracy of toxicological assessments.
In summary, the tumor microenvironment plays a critical role in cancer development, progression, and response to treatments. Its complex interactions with toxicants necessitate a comprehensive understanding in the field of Toxicology to develop more effective therapeutic strategies and improve cancer patient outcomes.
