How Does UGT1A1 Genetic Variation Affect Toxicology?
Genetic polymorphisms in the UGT1A1 gene can significantly influence the enzyme's activity. These variations can result in altered glucuronidation capacity, affecting drug metabolism and toxicity. For instance, the UGT1A1*28 polymorphism is associated with reduced enzyme activity, leading to conditions like Gilbert's syndrome, characterized by elevated levels of unconjugated bilirubin. In the context of drug metabolism, individuals with this polymorphism may experience increased toxicity or altered efficacy of drugs like irinotecan.
