In toxicology, UGT1A1 is of significant interest because it is involved in the metabolism and clearance of potentially harmful substances. The enzyme's ability to conjugate substances with glucuronic acid enhances their solubility, facilitating excretion via bile or urine. Dysfunction or variations in UGT1A1 activity can lead to the accumulation of toxic substances, impacting drug efficacy and increasing the risk of adverse drug reactions.
