What is the Role of UGT1A1 in Drug-Drug Interactions?
UGT1A1 is pivotal in mediating drug-drug interactions, particularly when multiple drugs are substrates of this enzyme. Co-administration of drugs that inhibit or induce UGT1A1 can alter the metabolism of other drugs, potentially leading to increased toxicity or reduced therapeutic effect. For example, inhibitors of UGT1A1 can elevate plasma concentrations of drugs metabolized by this enzyme, necessitating dose adjustments to avoid adverse effects.
