How is UGT1A1 Activity Assessed in Toxicology Studies?
Assessing UGT1A1 activity is crucial in toxicology studies to predict individual responses to drugs and identify potential risks associated with drug therapy. Activity can be evaluated using in vitro assays with recombinant enzymes, in vivo pharmacokinetic studies, or through genotyping to identify polymorphisms that may affect enzyme function. These assessments help in personalizing drug therapy and minimizing adverse effects.
