VKORC1 gene polymorphisms significantly influence warfarin sensitivity and dosage requirements. Variations in the VKORC1 gene can lead to either increased or decreased enzyme activity, impacting how effectively warfarin inhibits this enzyme. Individuals with certain VKORC1 variants may require lower doses of warfarin to achieve the same anticoagulant effect, highlighting the importance of personalized medicine in anticoagulation therapy.
