How is VKORC1 Related to Environmental Toxicology?
Beyond pharmaceuticals, VKORC1's role extends to environmental toxicology, particularly concerning rodenticides like brodifacoum, which are also vitamin K antagonists. Resistance to these compounds has been observed in some rodent populations due to mutations in the VKORC1 gene, complicating pest control efforts. Understanding these genetic adaptations is crucial for developing more effective and environmentally safe rodenticides.
