What are the Implications of VKORC1 Polymorphisms?
Polymorphisms in the VKORC1 gene can result in different phenotypes ranging from warfarin resistance to increased sensitivity. For instance, the VKORC1 -1639G>A polymorphism is associated with lower VKORC1 expression and increased sensitivity to warfarin. This genetic variability underscores the need for genetic testing before initiating warfarin therapy to avoid subtherapeutic or supratherapeutic doses, which can lead to complications like bleeding or thrombosis.
