The significance of VKORC1 in toxicology primarily stems from its role as a target of anticoagulant medications like warfarin. Warfarin, a commonly prescribed blood thinner, functions by inhibiting VKORC1, thus reducing the synthesis of active clotting factors. Understanding the pharmacogenomics of VKORC1 helps in predicting individual responses to warfarin, thereby preventing adverse drug reactions and optimizing therapeutic outcomes.
