Management of antidepressant toxicity involves several critical steps:
Decontamination - Activated charcoal may be administered to limit absorption if the overdose is recent. Supportive care - Monitoring and supporting vital functions such as airway, breathing, and circulation. Specific antidotes - For example, benzodiazepines may be used to control seizures, and intravenous lipid emulsion therapy can be considered for severe TCA toxicity. Serotonin Syndrome - Treated with discontinuation of serotonergic agents, supportive care, and medications like cyproheptadine.
