How is Deoxyguanosine Damage Detected and Measured?
Detection and quantification of deoxyguanosine damage, particularly 8-oxo-deoxyguanosine, is essential for understanding the impact of toxic exposures. Several methods are employed, including high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and immunoassays. These techniques allow researchers to assess the extent of DNA damage in cells and tissues, providing insights into the biological effects of various toxicants.
