What Are the Consequences of Deoxyguanosine Damage?
Damage to deoxyguanosine can have several consequences. The formation of 8-oxo-deoxyguanosine is one of the most studied lesions, as it can mispair with adenine during DNA replication, resulting in mutations. Such mutations can contribute to the development of cancer and other diseases. Furthermore, extensive damage to deoxyguanosine can trigger cellular responses, including apoptosis or senescence, impacting tissue function and organismal health.
