Haloperidol is metabolized in the liver through two main pathways: reduction and oxidation. The cytochrome P450 enzyme system, particularly CYP3A4, plays a significant role in its oxidative metabolism. The reduced form of haloperidol can be further oxidized to form various metabolites, some of which may contribute to its neurotoxic effects. Understanding the metabolism is crucial in toxicology to predict and manage potential drug interactions and side effects.
