Drug interactions can significantly impact the safety profile of haloperidol. Concomitant use with other medications that prolong the QT interval, such as certain antibiotics or antiarrhythmics, can enhance the risk of serious cardiac events. Additionally, drugs that inhibit CYP3A4, like ketoconazole or ritonavir, can increase haloperidol plasma levels, potentially leading to toxicity. It is crucial for healthcare providers to evaluate all concurrent medications to mitigate these risks.
