Researchers employ various methods to study HR, including genetic, biochemical, and cell-based assays. These methods can help determine the efficiency of HR in cells exposed to toxic substances. For example, the Comet assay and γ-H2AX foci formation are commonly used to detect DNA damage and repair efficiency. Additionally, advances in CRISPR/Cas9 technology have facilitated the creation of HR-deficient cell models to study the impact of specific gene disruptions on DNA repair.
