Despite their potential, the use of gene signatures in toxicology faces several challenges:
Complexity of Biological Systems: The complexity of biological responses to toxicants can make it difficult to identify clear and consistent gene signatures. Data Interpretation: The interpretation of gene expression data requires advanced bioinformatics tools and expertise, which can be a barrier for some research groups. Validation: Gene signatures must be validated across different experimental conditions and organisms to ensure their reliability and applicability.
