Nrf2 is a target for chemopreventive strategies aimed at enhancing the body's defense mechanisms against carcinogens. Natural compounds like curcumin, sulforaphane, and resveratrol have been shown to activate the Nrf2 pathway, promoting the expression of detoxifying enzymes and providing a protective effect against cancer development. These findings suggest that modulators of the Nrf2 pathway could be beneficial in preventing cancer and other diseases related to oxidative stress.