What are Potential Therapeutic Applications of Targeting Nrf2?
Given its role in cellular defense mechanisms, Nrf2 is a promising target for drug development. Nrf2 activators are being explored for their potential in treating diseases characterized by oxidative stress and inflammation, such as neurodegenerative diseases, diabetes, and cardiovascular diseases. However, therapeutic strategies must be carefully designed to avoid the unwanted side effects of chronic Nrf2 activation, such as potential cancer risk.
