Capsaicin is generally regarded as safe when used appropriately, but it can be toxic in high concentrations. Toxicity from capsaicin is rare but can occur when consumed in excessive amounts, leading to symptoms such as nausea, vomiting, abdominal pain, and even respiratory distress. Topical exposure can cause skin irritation and a burning sensation, and inhalation of capsaicin particles may irritate the respiratory tract.
