Hyperforin is thought to exert its effects by modulating the levels of certain neurotransmitters in the brain, such as serotonin, dopamine, and norepinephrine. It achieves this by inhibiting the reuptake of these neurotransmitters, thereby increasing their availability in the synaptic cleft. This mechanism is similar to that of some conventional antidepressant medications. However, hyperforin's exact mode of action is still not fully understood, and ongoing research aims to elucidate its pharmacodynamics.
