While hyperforin is generally considered safe when used appropriately, it is not without potential risks. One of the most significant concerns is its ability to induce the activity of the cytochrome P450 enzyme system, particularly CYP3A4. This can lead to increased metabolism of various drugs, potentially reducing their efficacy. Additionally, hyperforin may increase sensitivity to sunlight, leading to photosensitivity reactions in some individuals. Other side effects may include gastrointestinal disturbances, fatigue, and dizziness.
