What are Common Toxic Agents Causing Coagulopathy?
Several toxic agents can induce coagulopathy, including:
Warfarin and Superwarfarins: These are used as anticoagulant rodenticides and inhibit vitamin K epoxide reductase, essential for the synthesis of active clotting factors. Snake Venom: Some snakes, such as vipers and pit vipers, have venom that can cause coagulopathy by affecting platelet function or directly acting on the clotting cascade. Heparin: Though a therapeutic agent, overdose or contamination with other anticoagulant substances can lead to coagulopathy. Liver Toxins: Certain toxins like Amanita phalloides (death cap mushroom) can cause liver damage, impairing the synthesis of clotting factors.
