What are the Challenges Associated with HTS in Toxicology?
Despite its advantages, HTS in toxicology faces several challenges:
False Positives and Negatives: HTS can sometimes produce false results, leading to incorrect conclusions about a compound's toxicity. Rigorous validation of assays is required to minimize these errors. Complexity of Biological Systems: Simplified assays may not fully capture the complexity of biological systems, potentially missing critical toxicological effects that occur in vivo. Data Management: The vast amount of data generated by HTS needs robust data management and analysis tools to derive meaningful insights.
