Despite its potential as a therapeutic target, there are challenges associated with targeting KEAP1. The complexity of the KEAP1-Nrf2 interaction, as well as the diverse roles of Nrf2 in different tissues and disease states, make it difficult to predict the outcomes of modulating this pathway. Additionally, chronic activation of Nrf2 can contribute to cancer progression, underscoring the need for careful regulation and targeted approaches in therapeutic interventions.
In conclusion, KEAP1 is a critical player in the intricate balance of cellular responses to oxidative stress and toxic insults. Its role in regulating the Nrf2 pathway makes it a key focus of research in toxicology, with significant implications for understanding disease mechanisms and developing novel therapeutic strategies.
