Can KEAP1 be a target for therapeutic intervention?
Given its central role in regulating the Nrf2 pathway, KEAP1 is an attractive target for therapeutic intervention. Modulating the KEAP1-Nrf2 axis could potentially offer benefits in treating diseases characterized by oxidative stress, such as neurodegenerative disorders, cardiovascular diseases, and certain cancers. Pharmacological agents designed to disrupt the interaction between KEAP1 and Nrf2, or to mimic the effects of oxidative stress on KEAP1, are being explored as potential therapies.
