In the realm of chemoprevention, KEAP1 plays a crucial role by modulating the Nrf2 pathway. Many naturally occurring and synthetic compounds, known as Nrf2 activators, can induce the dissociation of the KEAP1-Nrf2 complex. This action results in the activation of Nrf2 and the subsequent upregulation of detoxifying enzymes and antioxidant proteins, thereby providing protection against chemical carcinogens and environmental toxins.
