What are the clinical implications of P-glycoprotein in drug development?
Understanding the role of P-glycoprotein is crucial in the drug development process. Screening for P-gp substrates and inhibitors is necessary to predict drug-drug interactions and optimize dosing regimens. Additionally, assessing the impact of P-gp on drug disposition helps in designing drugs with better therapeutic profiles and reduced toxicity. Personalized medicine approaches may also consider P-gp polymorphisms to tailor treatments based on individual transporter activity.
