P-glycoprotein is an ATP-dependent efflux pump found in the cell membranes of tissues such as the liver, intestines, kidneys, and the blood-brain barrier. It plays a pivotal role in the efflux of drugs and toxins out of cells, contributing to the protection of vital organs from potentially harmful substances. P-gp is encoded by the ABCB1 gene and is part of the larger ATP-binding cassette (ABC) transporter family.
