How does P-glycoprotein affect drug pharmacokinetics?
P-glycoprotein significantly impacts the absorption, distribution, and excretion of drugs. It can limit oral drug absorption by actively transporting substances back into the intestinal lumen, thus reducing their bioavailability. In the blood-brain barrier, P-gp restricts the entry of drugs into the central nervous system, influencing the therapeutic efficacy of central nervous system-active agents. Moreover, P-gp facilitates the excretion of drugs and their metabolites into bile and urine, affecting their elimination from the body.
