- Drugs: Certain medications can be hepatotoxic, especially when taken in high doses or for prolonged periods. Common examples include acetaminophen, statins, and antitubercular drugs such as isoniazid and rifampicin. - Alcohol: Chronic alcohol consumption is a major cause of liver damage, leading to conditions like fatty liver, alcoholic hepatitis, and cirrhosis. - Herbal Supplements: Some natural products and supplements, like kava and black cohosh, have been associated with liver toxicity. - Industrial Chemicals: Exposure to chemicals like carbon tetrachloride and vinyl chloride can also be hepatotoxic.