Drug reservoirs can play a significant role in drug toxicity. If a drug accumulates in a reservoir, it may lead to prolonged exposure and increased risk of adverse effects, especially if the reservoir site is sensitive to the drug's action. For instance, fat-soluble drugs stored in adipose tissue may be released slowly, causing prolonged effects even after dosing has ceased. Additionally, drugs that accumulate in specific organs, such as the liver or kidneys, may cause organ-specific toxicity.
