Several factors contribute to the formation of drug reservoirs:
Lipophilicity: Drugs with high lipid solubility are more likely to accumulate in fatty tissues, forming reservoirs. Protein Binding: Drugs that bind extensively to proteins in the blood can form reservoirs, as only the unbound fraction can exert therapeutic effects. Tissue Affinity: Some drugs have a natural affinity for certain tissues, such as tetracycline's affinity for bone. pH Differentials: Differences in pH between compartments can lead to ion trapping, creating reservoirs.
