In toxicology, TNFR1 is significant due to its involvement in mediating responses to toxic insults. When cells are exposed to toxic substances, TNFR1 can be activated, leading to either cell survival or death, depending on the context and cellular environment. This receptor can mediate apoptosis through the activation of caspase pathways, which is a common response to toxic chemical exposure. Additionally, TNFR1-induced inflammation can be a double-edged sword, providing necessary immune responses but also contributing to chronic inflammation and tissue damage if dysregulated.
