What are the Implications of Adenine in Genetic Disorders?
Mutations affecting adenine metabolism can lead to a range of genetic disorders. One such disorder is Lesch-Nyhan syndrome, which involves the overproduction of uric acid due to a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). Although adenine itself is not the direct cause, its involvement in the purine salvage pathway is crucial in understanding the disorder.
