What Are the Implications of Mitotic Spindle Disruption in Toxicology?
The disruption of the mitotic spindle by toxins can have severe implications. It can lead to carcinogenesis due to the propagation of cells with abnormal chromosome numbers. Additionally, spindle toxins are used therapeutically as anticancer drugs because they target rapidly dividing cancer cells. However, their impact on normal cells can cause side effects, emphasizing the need for targeted therapies that minimize collateral damage.
