What Are the Mechanisms of Liver Toxicity at the Cellular Level?
Mechanisms of liver toxicity often involve oxidative stress, mitochondrial dysfunction, and disruption of intracellular signaling pathways. Oxidative stress results from the overproduction of reactive oxygen species (ROS), leading to lipid peroxidation, DNA damage, and apoptosis. Mitochondrial dysfunction can result in ATP depletion and further oxidative stress. Disruption of intracellular signaling pathways can affect cell proliferation, apoptosis, and inflammatory responses, exacerbating liver damage.
